<?xml version="1.0" encoding="UTF-8"?>
<rdf:RDF
 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
 xmlns:owl="http://www.w3.org/2002/07/owl#"
 xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
 xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<owl:Ontology rdf:about="">
 <owl:imports rdf:resource="http://www.biopax.org/release/biopax-level3.owl#" />
</owl:Ontology>

<bp:RelationshipXref rdf:about="805b834e-88f7-4fd1-92f9-3a570f36ba6c">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">5294</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:Control rdf:about="3b44dcc5-3755-47d3-9b33-91d1221c32e2">
 <bp:controller rdf:resource="05267b53-5a9b-4467-8531-a00b3cfd07bb" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Control>

<bp:Control rdf:about="5dcb074f-5cdb-43a6-86af-733c2efcb98a">
 <bp:controlled rdf:resource="3b44dcc5-3755-47d3-9b33-91d1221c32e2" />
 <bp:controller rdf:resource="0e2d4aa2-6341-4054-ac9d-60e86ea98fc2" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Control>

<bp:ModificationFeature rdf:about="5e9ca2ea-9f5b-4274-a062-2fe8a1ea6fd0">
 <bp:modificationType rdf:resource="a7e5ffa0-9e9c-4686-ba48-b3835886041c" />
</bp:ModificationFeature>

<bp:PublicationXref rdf:about="3f7e9509-9fa0-430d-9862-c9df6706153c">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">33741342</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">pmid</bp:db>
</bp:PublicationXref>

<bp:BioSource rdf:about="33490865-a704-4e29-b207-f9d2d0be2f30">
 <bp:xref rdf:resource="c31e7f8e-3bcc-4f20-8aab-971485ed39c8" />
</bp:BioSource>

<bp:Control rdf:about="80a2c024-afd8-4500-b626-c3394ced652c">
 <bp:controller rdf:resource="0e2d4aa2-6341-4054-ac9d-60e86ea98fc2" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Control>

<bp:ProteinReference rdf:about="ee86207d-7603-4839-a2f7-000bd73e1ae1">
 <bp:xref rdf:resource="805b834e-88f7-4fd1-92f9-3a570f36ba6c" />
 <bp:organism rdf:resource="33490865-a704-4e29-b207-f9d2d0be2f30" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PI3K</bp:displayName>
</bp:ProteinReference>

<bp:UnificationXref rdf:about="b396be3f-6ec4-45b3-b846-c8cd6d6fc6c3">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">c0e87310-38bb-4ffd-aa5b-93bb2306392c</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">BioFactoid</bp:db>
</bp:UnificationXref>

<bp:RelationshipXref rdf:about="e17bee28-f527-4c32-8852-c47ca5dfdad4">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">5879</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:RelationshipXref rdf:about="63ca99fa-84a8-4100-a382-10fe432b6d89">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">4088</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:ProteinReference rdf:about="7acce445-1267-468d-8bfb-0f4ec9feac84">
 <bp:entityFeature rdf:resource="5e9ca2ea-9f5b-4274-a062-2fe8a1ea6fd0" />
 <bp:entityFeature rdf:resource="d84fe8c1-ab45-473c-b945-075e84cd6a50" />
 <bp:xref rdf:resource="63ca99fa-84a8-4100-a382-10fe432b6d89" />
 <bp:organism rdf:resource="33490865-a704-4e29-b207-f9d2d0be2f30" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Smad3</bp:displayName>
</bp:ProteinReference>

<bp:Protein rdf:about="cec345d5-f987-4379-9b41-3c5e232a31af">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Smad3</bp:displayName>
 <bp:entityReference rdf:resource="7acce445-1267-468d-8bfb-0f4ec9feac84" />
</bp:Protein>

<bp:Protein rdf:about="fb8984a7-caaa-40d0-b548-317d48ee236b">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PI3K</bp:displayName>
 <bp:entityReference rdf:resource="ee86207d-7603-4839-a2f7-000bd73e1ae1" />
</bp:Protein>

<bp:Control rdf:about="1b640f27-208c-49ee-92b2-c08aeeea170b">
 <bp:controller rdf:resource="05267b53-5a9b-4467-8531-a00b3cfd07bb" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">INHIBITION</bp:controlType>
</bp:Control>

<bp:Control rdf:about="e6a89926-9529-4bb6-84bf-7e55357ae1ae">
 <bp:controlled rdf:resource="1b640f27-208c-49ee-92b2-c08aeeea170b" />
 <bp:controller rdf:resource="36c08644-10f3-4e55-b9f5-3f9f0d14fe7d" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">INHIBITION</bp:controlType>
</bp:Control>

<bp:Protein rdf:about="05267b53-5a9b-4467-8531-a00b3cfd07bb">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Rac1</bp:displayName>
 <bp:entityReference rdf:resource="13d6479e-b1e8-4c99-bcb8-ca8abc1fdc41" />
</bp:Protein>

<bp:Protein rdf:about="36c08644-10f3-4e55-b9f5-3f9f0d14fe7d">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ARHGAP24</bp:displayName>
 <bp:entityReference rdf:resource="2aab605c-a627-4991-a30e-07bffa217330" />
</bp:Protein>

<bp:TemplateReactionRegulation rdf:about="48fe4a4b-118b-4ed7-9144-41bcd178646b">
 <bp:controlled rdf:resource="873c8026-d53c-45e0-98c8-a23b5c3245d8" />
 <bp:controller rdf:resource="cec345d5-f987-4379-9b41-3c5e232a31af" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">INHIBITION</bp:controlType>
</bp:TemplateReactionRegulation>

<bp:Protein rdf:about="5b814c86-c039-4874-9b30-0a43f9dd98e0">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Smad3</bp:displayName>
 <bp:feature rdf:resource="5e9ca2ea-9f5b-4274-a062-2fe8a1ea6fd0" />
 <bp:feature rdf:resource="d84fe8c1-ab45-473c-b945-075e84cd6a50" />
 <bp:entityReference rdf:resource="7acce445-1267-468d-8bfb-0f4ec9feac84" />
</bp:Protein>

<bp:RelationshipXref rdf:about="1f1decf2-ec9f-453d-a929-bc1f2078f52a">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">83478</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:Protein rdf:about="a9699804-0f83-463d-8528-41b6d86881d1">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Smad3</bp:displayName>
 <bp:entityReference rdf:resource="7acce445-1267-468d-8bfb-0f4ec9feac84" />
 <bp:notFeature rdf:resource="5e9ca2ea-9f5b-4274-a062-2fe8a1ea6fd0" />
 <bp:notFeature rdf:resource="d84fe8c1-ab45-473c-b945-075e84cd6a50" />
</bp:Protein>

<bp:Control rdf:about="4a1b4d7f-3537-47de-bbfb-3aff437797c7">
 <bp:controlled rdf:resource="80a2c024-afd8-4500-b626-c3394ced652c" />
 <bp:controller rdf:resource="fb8984a7-caaa-40d0-b548-317d48ee236b" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Control>

<bp:TemplateReaction rdf:about="873c8026-d53c-45e0-98c8-a23b5c3245d8">
 <bp:product rdf:resource="36c08644-10f3-4e55-b9f5-3f9f0d14fe7d" />
 <bp:participant rdf:resource="36c08644-10f3-4e55-b9f5-3f9f0d14fe7d" />
</bp:TemplateReaction>

<bp:Protein rdf:about="0e2d4aa2-6341-4054-ac9d-60e86ea98fc2">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">(GEF)</bp:displayName>
 <bp:entityReference rdf:resource="a0e9a78f-6aa3-444b-87fa-9d5514fd0e57" />
</bp:Protein>

<bp:UnificationXref rdf:about="c31e7f8e-3bcc-4f20-8aab-971485ed39c8">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">9606</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">taxonomy</bp:db>
</bp:UnificationXref>

<bp:ProteinReference rdf:about="13d6479e-b1e8-4c99-bcb8-ca8abc1fdc41">
 <bp:xref rdf:resource="e17bee28-f527-4c32-8852-c47ca5dfdad4" />
 <bp:organism rdf:resource="33490865-a704-4e29-b207-f9d2d0be2f30" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Rac1</bp:displayName>
</bp:ProteinReference>

<bp:ProteinReference rdf:about="2aab605c-a627-4991-a30e-07bffa217330">
 <bp:xref rdf:resource="1f1decf2-ec9f-453d-a929-bc1f2078f52a" />
 <bp:organism rdf:resource="33490865-a704-4e29-b207-f9d2d0be2f30" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ARHGAP24</bp:displayName>
</bp:ProteinReference>

<bp:ModificationFeature rdf:about="d84fe8c1-ab45-473c-b945-075e84cd6a50">
 <bp:modificationType rdf:resource="a29a82ea-60bf-4547-9899-34229dd19149" />
</bp:ModificationFeature>

<bp:Conversion rdf:about="2aebfd15-3f9c-4fd0-99ac-1072d645b73c">
 <bp:right rdf:resource="5b814c86-c039-4874-9b30-0a43f9dd98e0" />
 <bp:left rdf:resource="a9699804-0f83-463d-8528-41b6d86881d1" />
 <bp:conversionDirection rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">LEFT_TO_RIGHT</bp:conversionDirection>
</bp:Conversion>

<bp:ProteinReference rdf:about="a0e9a78f-6aa3-444b-87fa-9d5514fd0e57">
 <bp:xref rdf:resource="bc79b709-cda1-46d7-8af4-6386c71615b1" />
 <bp:organism rdf:resource="33490865-a704-4e29-b207-f9d2d0be2f30" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">(GEF)</bp:displayName>
</bp:ProteinReference>

<bp:Catalysis rdf:about="2af7ee6c-fe32-4f15-af97-5bebbfc59ece">
 <bp:controller rdf:resource="1d917416-31aa-4ddd-aba4-c2d1d986f1c8" />
 <bp:controlled rdf:resource="2aebfd15-3f9c-4fd0-99ac-1072d645b73c" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Catalysis>

<bp:Control rdf:about="bab47110-a88c-4d98-be2f-b79229e5c2ad">
 <bp:controlled rdf:resource="b9eb3833-a1d6-4ff3-93b1-c82aa822dcf6" />
 <bp:controller rdf:resource="1d917416-31aa-4ddd-aba4-c2d1d986f1c8" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Control>

<bp:Control rdf:about="b9eb3833-a1d6-4ff3-93b1-c82aa822dcf6">
 <bp:controller rdf:resource="fb8984a7-caaa-40d0-b548-317d48ee236b" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Control>

<bp:SequenceModificationVocabulary rdf:about="a7e5ffa0-9e9c-4686-ba48-b3835886041c">
 <bp:term rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">active</bp:term>
</bp:SequenceModificationVocabulary>

<bp:Pathway rdf:about="12d2338e-ece7-4a0c-9083-69cab1eabcd8">
 <bp:pathwayComponent rdf:resource="2aebfd15-3f9c-4fd0-99ac-1072d645b73c" />
 <bp:pathwayComponent rdf:resource="3b44dcc5-3755-47d3-9b33-91d1221c32e2" />
 <bp:pathwayComponent rdf:resource="5dcb074f-5cdb-43a6-86af-733c2efcb98a" />
 <bp:pathwayComponent rdf:resource="2af7ee6c-fe32-4f15-af97-5bebbfc59ece" />
 <bp:pathwayComponent rdf:resource="bab47110-a88c-4d98-be2f-b79229e5c2ad" />
 <bp:pathwayComponent rdf:resource="4a1b4d7f-3537-47de-bbfb-3aff437797c7" />
 <bp:pathwayComponent rdf:resource="b9eb3833-a1d6-4ff3-93b1-c82aa822dcf6" />
 <bp:pathwayComponent rdf:resource="873c8026-d53c-45e0-98c8-a23b5c3245d8" />
 <bp:pathwayComponent rdf:resource="80a2c024-afd8-4500-b626-c3394ced652c" />
 <bp:pathwayComponent rdf:resource="1b640f27-208c-49ee-92b2-c08aeeea170b" />
 <bp:pathwayComponent rdf:resource="e6a89926-9529-4bb6-84bf-7e55357ae1ae" />
 <bp:pathwayComponent rdf:resource="48fe4a4b-118b-4ed7-9144-41bcd178646b" />
 <bp:xref rdf:resource="3f7e9509-9fa0-430d-9862-c9df6706153c" />
 <bp:xref rdf:resource="b396be3f-6ec4-45b3-b846-c8cd6d6fc6c3" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">TGF-β-induced cell motility requires downregulation of ARHGAPs to sustain Rac1 activity.</bp:displayName>
</bp:Pathway>

<bp:SequenceModificationVocabulary rdf:about="a29a82ea-60bf-4547-9899-34229dd19149">
 <bp:term rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">phosphorylated</bp:term>
</bp:SequenceModificationVocabulary>

<bp:ProteinReference rdf:about="11514a0a-e5d9-434c-ba97-9d25f70ffaaa">
 <bp:xref rdf:resource="0b79555a-e7af-4876-9a50-ffe73e29d863" />
 <bp:organism rdf:resource="33490865-a704-4e29-b207-f9d2d0be2f30" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">TGF-beta</bp:displayName>
</bp:ProteinReference>

<bp:Protein rdf:about="1d917416-31aa-4ddd-aba4-c2d1d986f1c8">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">TGF-beta</bp:displayName>
 <bp:entityReference rdf:resource="11514a0a-e5d9-434c-ba97-9d25f70ffaaa" />
</bp:Protein>

<bp:RelationshipXref rdf:about="0b79555a-e7af-4876-9a50-ffe73e29d863">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">7040</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:RelationshipXref rdf:about="bc79b709-cda1-46d7-8af4-6386c71615b1">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">9181</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>
</rdf:RDF>