<?xml version="1.0" encoding="UTF-8"?>
<rdf:RDF
 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
 xmlns:owl="http://www.w3.org/2002/07/owl#"
 xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
 xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<owl:Ontology rdf:about="">
 <owl:imports rdf:resource="http://www.biopax.org/release/biopax-level3.owl#" />
</owl:Ontology>

<bp:BioSource rdf:about="a154d80e-e8b9-40df-832d-fe462eb5c40a">
 <bp:xref rdf:resource="d884c7e4-e392-4eac-89a2-a37363b4a016" />
</bp:BioSource>

<bp:Protein rdf:about="bbe8851b-bd42-4edb-8d11-332425ac84bd">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NRF2</bp:displayName>
 <bp:entityReference rdf:resource="2c613a59-febc-40b0-bacd-4b84c16bd05d" />
</bp:Protein>

<bp:RelationshipXref rdf:about="936f1066-ec9e-4cf0-bc97-6166c94dc46f">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">4780</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:UnificationXref rdf:about="d884c7e4-e392-4eac-89a2-a37363b4a016">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">9606</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">taxonomy</bp:db>
</bp:UnificationXref>

<bp:TemplateReactionRegulation rdf:about="c260c04d-b004-4bd6-be19-c4df74350a10">
 <bp:controlled rdf:resource="ba917bdb-3edc-4a6f-a748-224eade32964" />
 <bp:controller rdf:resource="29fc14ab-738c-44c1-8358-6fee54592d46" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:TemplateReactionRegulation>

<bp:Catalysis rdf:about="06615183-8f51-4021-ba58-61f25b40c790">
 <bp:controller rdf:resource="64a890b6-8779-4aa7-b216-91d2195baba1" />
 <bp:controlled rdf:resource="c148ceb9-3177-46fa-b92a-24014f115be2" />
</bp:Catalysis>

<bp:RelationshipXref rdf:about="f968fe39-3c0e-4ac1-ac8a-2221025630c2">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">468</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:Protein rdf:about="64a890b6-8779-4aa7-b216-91d2195baba1">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CHAC1</bp:displayName>
 <bp:entityReference rdf:resource="fad4e1aa-1024-4502-b847-dc9980422d3d" />
</bp:Protein>

<bp:Protein rdf:about="29fc14ab-738c-44c1-8358-6fee54592d46">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ATF4</bp:displayName>
 <bp:entityReference rdf:resource="92f2b89f-4b26-4406-bcb6-1c67bfa1a7d8" />
</bp:Protein>

<bp:SmallMolecule rdf:about="08b17089-29f0-4eaf-9f71-196643a61d0d">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">glutathione</bp:displayName>
 <bp:entityReference rdf:resource="aab3819e-98a7-4a73-9423-e9f7ba449ee7" />
</bp:SmallMolecule>

<bp:UnificationXref rdf:about="c66fd873-aef7-4c00-ac50-211815ded71d">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">4090b8cc-4ad1-4b74-abc7-b7d3fd392897</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">BioFactoid</bp:db>
</bp:UnificationXref>

<bp:Pathway rdf:about="84eefc63-460e-4d8a-bca9-fdf8a0dec259">
 <bp:pathwayComponent rdf:resource="ba917bdb-3edc-4a6f-a748-224eade32964" />
 <bp:pathwayComponent rdf:resource="c260c04d-b004-4bd6-be19-c4df74350a10" />
 <bp:pathwayComponent rdf:resource="dc0cd4d5-8777-44ac-bcee-8ba0aa9c942e" />
 <bp:pathwayComponent rdf:resource="c148ceb9-3177-46fa-b92a-24014f115be2" />
 <bp:pathwayComponent rdf:resource="bbb6be57-7a25-4cb3-8279-74c6727b3e86" />
 <bp:pathwayComponent rdf:resource="06615183-8f51-4021-ba58-61f25b40c790" />
 <bp:pathwayComponent rdf:resource="891e79ff-152c-413a-83df-ab08c3e3bea4" />
 <bp:pathwayComponent rdf:resource="b16a935b-2ada-4725-b1b2-9b73a74f44e5" />
 <bp:pathwayComponent rdf:resource="58a29d63-deeb-4109-913b-a4e317c84cbc" />
 <bp:pathwayComponent rdf:resource="66baba2a-ee42-4629-abed-442bb48d3969" />
 <bp:xref rdf:resource="c66fd873-aef7-4c00-ac50-211815ded71d" />
 <bp:xref rdf:resource="366e5ff0-ead8-4c71-ad48-2014b69ef837" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2.</bp:displayName>
</bp:Pathway>

<bp:ProteinReference rdf:about="92f2b89f-4b26-4406-bcb6-1c67bfa1a7d8">
 <bp:xref rdf:resource="f968fe39-3c0e-4ac1-ac8a-2221025630c2" />
 <bp:organism rdf:resource="a154d80e-e8b9-40df-832d-fe462eb5c40a" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ATF4</bp:displayName>
</bp:ProteinReference>

<bp:Catalysis rdf:about="891e79ff-152c-413a-83df-ab08c3e3bea4">
 <bp:controller rdf:resource="bbe8851b-bd42-4edb-8d11-332425ac84bd" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Catalysis>

<bp:TemplateReactionRegulation rdf:about="66baba2a-ee42-4629-abed-442bb48d3969">
 <bp:controlled rdf:resource="58a29d63-deeb-4109-913b-a4e317c84cbc" />
 <bp:controller rdf:resource="e4e7066b-d2ed-42fa-8b8f-79cc354e5a5e" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:TemplateReactionRegulation>

<bp:ProteinReference rdf:about="2c613a59-febc-40b0-bacd-4b84c16bd05d">
 <bp:xref rdf:resource="95642104-dca0-45d9-86ff-c9764f3de9ff" />
 <bp:organism rdf:resource="a154d80e-e8b9-40df-832d-fe462eb5c40a" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NRF2</bp:displayName>
</bp:ProteinReference>

<bp:Protein rdf:about="e4e7066b-d2ed-42fa-8b8f-79cc354e5a5e">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NFE2L2</bp:displayName>
 <bp:entityReference rdf:resource="6f207a21-5cc9-414b-ba72-7095a90ddf96" />
</bp:Protein>

<bp:BiochemicalReaction rdf:about="c148ceb9-3177-46fa-b92a-24014f115be2">
 <bp:left rdf:resource="08b17089-29f0-4eaf-9f71-196643a61d0d" />
 <bp:conversionDirection rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">LEFT_TO_RIGHT</bp:conversionDirection>
</bp:BiochemicalReaction>

<bp:SmallMoleculeReference rdf:about="aab3819e-98a7-4a73-9423-e9f7ba449ee7">
 <bp:xref rdf:resource="6a153e23-1b74-40e9-abe8-2136c5f4820f" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">glutathione</bp:displayName>
</bp:SmallMoleculeReference>

<bp:RelationshipXref rdf:about="95642104-dca0-45d9-86ff-c9764f3de9ff">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">2551</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:RelationshipXref rdf:about="6a153e23-1b74-40e9-abe8-2136c5f4820f">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">16856</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChEBI</bp:db>
</bp:RelationshipXref>

<bp:TemplateReaction rdf:about="58a29d63-deeb-4109-913b-a4e317c84cbc">
 <bp:product rdf:resource="bbe8851b-bd42-4edb-8d11-332425ac84bd" />
 <bp:participant rdf:resource="bbe8851b-bd42-4edb-8d11-332425ac84bd" />
</bp:TemplateReaction>

<bp:TemplateReaction rdf:about="ba917bdb-3edc-4a6f-a748-224eade32964">
 <bp:product rdf:resource="e4e7066b-d2ed-42fa-8b8f-79cc354e5a5e" />
 <bp:participant rdf:resource="e4e7066b-d2ed-42fa-8b8f-79cc354e5a5e" />
</bp:TemplateReaction>

<bp:ProteinReference rdf:about="6f207a21-5cc9-414b-ba72-7095a90ddf96">
 <bp:xref rdf:resource="936f1066-ec9e-4cf0-bc97-6166c94dc46f" />
 <bp:organism rdf:resource="a154d80e-e8b9-40df-832d-fe462eb5c40a" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NFE2L2</bp:displayName>
</bp:ProteinReference>

<bp:TemplateReaction rdf:about="dc0cd4d5-8777-44ac-bcee-8ba0aa9c942e">
 <bp:product rdf:resource="64a890b6-8779-4aa7-b216-91d2195baba1" />
 <bp:participant rdf:resource="64a890b6-8779-4aa7-b216-91d2195baba1" />
</bp:TemplateReaction>

<bp:Modulation rdf:about="bbb6be57-7a25-4cb3-8279-74c6727b3e86">
 <bp:controlled rdf:resource="891e79ff-152c-413a-83df-ab08c3e3bea4" />
 <bp:controller rdf:resource="08b17089-29f0-4eaf-9f71-196643a61d0d" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">INHIBITION</bp:controlType>
</bp:Modulation>

<bp:PublicationXref rdf:about="366e5ff0-ead8-4c71-ad48-2014b69ef837">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">37410595</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">pmid</bp:db>
</bp:PublicationXref>

<bp:RelationshipXref rdf:about="f3d27ea4-e08b-48b8-a45b-021397d38c0d">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">79094</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:TemplateReactionRegulation rdf:about="b16a935b-2ada-4725-b1b2-9b73a74f44e5">
 <bp:controlled rdf:resource="dc0cd4d5-8777-44ac-bcee-8ba0aa9c942e" />
 <bp:controller rdf:resource="29fc14ab-738c-44c1-8358-6fee54592d46" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:TemplateReactionRegulation>

<bp:ProteinReference rdf:about="fad4e1aa-1024-4502-b847-dc9980422d3d">
 <bp:xref rdf:resource="f3d27ea4-e08b-48b8-a45b-021397d38c0d" />
 <bp:organism rdf:resource="a154d80e-e8b9-40df-832d-fe462eb5c40a" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CHAC1</bp:displayName>
</bp:ProteinReference>
</rdf:RDF>