{"id":"bfc12685-34b4-46f8-ac72-1773781e4072","secret":"read-only","organisms":["3702"],"elements":[{"id":"f081de53-703d-4c83-bb34-d9aec65d0382","secret":"read-only","position":{"x":345.3164556962025,"y":116.45569620253166},"name":"NPR1","description":"","type":"protein","completed":true,"association":{"combinedOrganismIndex":8,"dbName":"NCBI Gene","dbPrefix":"ncbigene","dbXrefs":[{"db":"Araport","id":"AT1G64280"},{"db":"TAIR","id":"AT1G64280"}],"defaultOrganismIndex":8,"distance":0,"esScore":11.3388,"id":"842733","name":"NPR1","nameDistance":0,"namespace":"ncbi","organism":"3702","organismIndex":0,"organismName":"Arabidopsis thaliana","overallDistance":800000,"shortSynonyms":["ARABIDOPSIS NONEXPRESSER OF PR GENES 1","ATNPR1","F15H21.6","F15H21_6","NIM1","REGULATORY PROTEIN NPR1","regulatory protein (NPR1)","NONEXPRESSER OF PR GENES 1","NON-INDUCIBLE IMMUNITY 1","SAI1"],"synonyms":["ARABIDOPSIS NONEXPRESSER OF PR GENES 1","ATNPR1","F15H21.6","F15H21_6","NIM1","NON-INDUCIBLE IMMUNITY 1","NONEXPRESSER OF PR GENES 1","REGULATORY PROTEIN NPR1","SAI1","SALICYLIC ACID INSENSITIVE 1","regulatory protein (NPR1)"],"type":"protein"}},{"id":"769d2ac5-2dc4-462d-8f9f-3e2e8265635d","secret":"read-only","position":{"x":414.17721518987344,"y":166.0759493670886},"name":"EIN3","description":"","type":"protein","completed":true,"association":{"charge":null,"combinedOrganismIndex":0,"dbName":"NCBI Gene","dbPrefix":"ncbigene","dbXrefs":[{"db":"Araport","id":"AT3G20770"},{"db":"TAIR","id":"AT3G20770"}],"defaultOrganismIndex":8,"distance":0,"esScore":11.863279,"formulae":null,"id":"821625","inchi":null,"inchiKey":null,"mass":null,"monoisotopicMass":null,"name":"EIN3","nameDistance":0,"namespace":"ncbi","organism":"3702","organismIndex":0,"organismName":"Arabidopsis thaliana","overallDistance":0,"shortSynonyms":["AtEIN3","ETHYLENE-INSENSITIVE3","Ethylene insensitive 3 family protein"],"synonyms":["AtEIN3","ETHYLENE-INSENSITIVE3","Ethylene insensitive 3 family protein"],"type":"protein"}},{"id":"fc7dc9c7-69c4-4cdb-85cc-e34c985e6c97","secret":"read-only","position":{"x":55.69620253164557,"y":60.75949367088607},"name":"","description":"","type":"binding","completed":true,"association":"binding","novel":true,"entries":[{"group":null,"id":"f081de53-703d-4c83-bb34-d9aec65d0382"},{"group":"positive","id":"769d2ac5-2dc4-462d-8f9f-3e2e8265635d"}]}],"publicUrl":"/document/bfc12685-34b4-46f8-ac72-1773781e4072","privateUrl":"/document/bfc12685-34b4-46f8-ac72-1773781e4072","citation":{"title":"Salicylic acid and ethylene coordinately promote leaf senescence.","authors":{"abbreviation":"Xiaodong Yu, Yiren Xu, Shunping Yan","contacts":[],"authorList":[{"name":"Xiaodong Yu","ForeName":"Xiaodong","LastName":"Yu","email":null,"abbrevName":"Yu X","isCollectiveName":false,"orcid":null},{"name":"Yiren Xu","ForeName":"Yiren","LastName":"Xu","email":null,"abbrevName":"Xu Y","isCollectiveName":false,"orcid":null},{"name":"Shunping Yan","ForeName":"Shunping","LastName":"Yan","email":null,"abbrevName":"Yan S","isCollectiveName":false,"orcid":null}]},"reference":"J Integr Plant Biol 63 2021","abstract":"Leaf senescence is an intrinsic biological process of plants. The phytohormones salicylic acid (SA) and ethylene (ET) are known to promote senescence. However, their relationship in this process is still unclear. We found that EIN3 and EIL1, two key transcription factors in ET signaling, are required for SA-induced leaf senescence in Arabidopsis. Furthermore, ET enhances the effect of SA in promoting senescence. Biochemical studies revealed that NPR1, the master regulator of SA signaling, interacts with EIN3 to promote its transcriptional activity. Our study suggests that SA and ET function coordinately in senescence, which is in contrast to their antagonistic crosstalk in other biological processes.","pmid":"33501782","doi":"10.1111/jipb.13074","pubTypes":[{"UI":"D016428","value":"Journal Article"}],"ISODate":"2021-05-01T00:00:00.000Z","relations":[]},"text":"NPR1 activates EIN3 via binding.","createdDate":"2022-09-21T03:03:32.000Z","lastEditedDate":"2022-09-21T03:04:22.000Z","status":"public","verified":false,"authorProfiles":[{"ForeName":"Xiaodong","LastName":"Yu","abbrevName":"Yu X","email":null,"isCollectiveName":false,"name":"Xiaodong Yu","orcid":null},{"ForeName":"Yiren","LastName":"Xu","abbrevName":"Xu Y","email":null,"isCollectiveName":false,"name":"Yiren Xu","orcid":null},{"ForeName":"Shunping","LastName":"Yan","abbrevName":"Yan S","email":null,"isCollectiveName":false,"name":"Shunping Yan","orcid":"0000-0002-3665-1310"}],"caption":"senescence"}