<?xml version="1.0" encoding="UTF-8"?>
<rdf:RDF
 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
 xmlns:owl="http://www.w3.org/2002/07/owl#"
 xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
 xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<owl:Ontology rdf:about="">
 <owl:imports rdf:resource="http://www.biopax.org/release/biopax-level3.owl#" />
</owl:Ontology>

<bp:Catalysis rdf:about="da7ff783-1b6a-451c-b7a1-5e268a47729e">
 <bp:controller rdf:resource="6aed25f2-c8db-4883-9a64-2b8f05146c76" />
 <bp:controlled rdf:resource="0ecd6353-910f-43f1-8ee5-14ad8baa9ef5" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Catalysis>

<bp:Pathway rdf:about="bcaff375-7fd9-4d80-97e8-6fc7ecd1ac30">
 <bp:pathwayComponent rdf:resource="9291ffee-58bd-4c59-b0ec-91cb9bd7e799" />
 <bp:pathwayComponent rdf:resource="da7ff783-1b6a-451c-b7a1-5e268a47729e" />
 <bp:pathwayComponent rdf:resource="8c97512f-6eaa-4ea1-904b-c6fb0efbc58e" />
 <bp:pathwayComponent rdf:resource="f452d86c-8937-40e3-9831-5a2d5b34e1ef" />
 <bp:pathwayComponent rdf:resource="334b5012-c70b-4b81-889c-fc9db9d49a46" />
 <bp:pathwayComponent rdf:resource="3a9a6c1f-7bfa-46ba-9dd7-f35fdd15c196" />
 <bp:pathwayComponent rdf:resource="9a37bbdc-c797-40a3-bb3c-474508a1ef26" />
 <bp:pathwayComponent rdf:resource="8fa7f4fa-8d58-4c5e-ab3c-af284de38305" />
 <bp:pathwayComponent rdf:resource="9161f301-b7df-4fb0-abea-925959d50b35" />
 <bp:pathwayComponent rdf:resource="0ecd6353-910f-43f1-8ee5-14ad8baa9ef5" />
 <bp:pathwayComponent rdf:resource="c73e6729-a81a-48eb-b82f-b051820675bf" />
 <bp:xref rdf:resource="f66aaf86-f904-4fde-8fa6-740c66d68cec" />
 <bp:xref rdf:resource="9870e8ad-ce7d-415d-8d29-d4fbb108eb95" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">An miRNA derived from amelogenin exon4 regulates expression of transcription factor Runx2 by directly targeting upstream activators Nfia and Prkch.</bp:displayName>
</bp:Pathway>

<bp:Interaction rdf:about="334b5012-c70b-4b81-889c-fc9db9d49a46">
 <bp:participant rdf:resource="9228158f-b69b-4cec-a390-42b273664d29" />
 <bp:participant rdf:resource="8bac2aba-b94f-4a6f-ad84-1e5381c190bc" />
</bp:Interaction>

<bp:ProteinReference rdf:about="2ab6b20e-d3a1-44b7-a969-139d6c930e9f">
 <bp:xref rdf:resource="330aa3dc-b4e9-45a0-ba86-63371525c6b5" />
 <bp:organism rdf:resource="dc2dc0ae-8db8-4c40-b246-16b838e8df54" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PKC eta</bp:displayName>
</bp:ProteinReference>

<bp:Catalysis rdf:about="9a37bbdc-c797-40a3-bb3c-474508a1ef26">
 <bp:controller rdf:resource="9228158f-b69b-4cec-a390-42b273664d29" />
 <bp:controlled rdf:resource="8c97512f-6eaa-4ea1-904b-c6fb0efbc58e" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Catalysis>

<bp:SmallMolecule rdf:about="8bac2aba-b94f-4a6f-ad84-1e5381c190bc">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">miRNA (miR-exon4)</bp:displayName>
 <bp:entityReference rdf:resource="926fdb9f-1a6d-483e-93ff-20292f549c56" />
</bp:SmallMolecule>

<bp:BioSource rdf:about="dc2dc0ae-8db8-4c40-b246-16b838e8df54">
 <bp:xref rdf:resource="22a6e669-1a7c-4531-b528-d5810ff5acfd" />
</bp:BioSource>

<bp:RnaReference rdf:about="af256a24-da76-4319-9b7c-7c1ef03448f7">
 <bp:xref rdf:resource="62008b5b-fb86-4a7c-830e-5aa2a5ce0e15" />
 <bp:organism rdf:resource="dc2dc0ae-8db8-4c40-b246-16b838e8df54" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Runx2</bp:displayName>
</bp:RnaReference>

<bp:Conversion rdf:about="8c97512f-6eaa-4ea1-904b-c6fb0efbc58e">
 <bp:right rdf:resource="a7a057e3-d0dc-444a-b609-6f2c7b60bb6a" />
 <bp:left rdf:resource="88d34051-d0b8-4776-83e6-f3657f46e08c" />
 <bp:conversionDirection rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">LEFT_TO_RIGHT</bp:conversionDirection>
</bp:Conversion>

<bp:SequenceModificationVocabulary rdf:about="efe95f0c-3332-4a8a-8b2b-ac977daeee07">
 <bp:term rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">phosphorylated</bp:term>
</bp:SequenceModificationVocabulary>

<bp:SequenceModificationVocabulary rdf:about="794843e7-0b23-45a2-893a-82c88899d57a">
 <bp:term rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">active</bp:term>
</bp:SequenceModificationVocabulary>

<bp:UnificationXref rdf:about="f66aaf86-f904-4fde-8fa6-740c66d68cec">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">4564a903-862c-4e57-9be0-e9a7da3cf304</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">BioFactoid</bp:db>
</bp:UnificationXref>

<bp:Protein rdf:about="b5c6af1e-3e0a-46f5-ba74-ff6532d3bf66">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">RUNX2</bp:displayName>
 <bp:entityReference rdf:resource="a922e830-076a-4ea5-80e2-f4d66e419493" />
</bp:Protein>

<bp:RelationshipXref rdf:about="86b3460a-851f-41da-9990-0f5b5a248255">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">15243</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChEBI</bp:db>
</bp:RelationshipXref>

<bp:RelationshipXref rdf:about="b7329df4-8e57-49f7-9eb0-7ae64bc85e21">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">18027</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:RnaReference rdf:about="f94a94a0-4f85-4cee-9206-09161bfbee1e">
 <bp:xref rdf:resource="b7329df4-8e57-49f7-9eb0-7ae64bc85e21" />
 <bp:organism rdf:resource="dc2dc0ae-8db8-4c40-b246-16b838e8df54" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NFIA</bp:displayName>
</bp:RnaReference>

<bp:ProteinReference rdf:about="a922e830-076a-4ea5-80e2-f4d66e419493">
 <bp:xref rdf:resource="62008b5b-fb86-4a7c-830e-5aa2a5ce0e15" />
 <bp:organism rdf:resource="dc2dc0ae-8db8-4c40-b246-16b838e8df54" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">RUNX2</bp:displayName>
</bp:ProteinReference>

<bp:RelationshipXref rdf:about="5cb461a2-c400-46c3-aab0-30a089845d28">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">56717</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:ModificationFeature rdf:about="bbe1f82c-ee2c-4a71-8e78-601ff73b10a8">
 <bp:modificationType rdf:resource="794843e7-0b23-45a2-893a-82c88899d57a" />
</bp:ModificationFeature>

<bp:Interaction rdf:about="8fa7f4fa-8d58-4c5e-ab3c-af284de38305">
 <bp:participant rdf:resource="8bac2aba-b94f-4a6f-ad84-1e5381c190bc" />
 <bp:participant rdf:resource="5949bd63-54d4-4c63-94dd-068602b3ddad" />
</bp:Interaction>

<bp:RelationshipXref rdf:about="62008b5b-fb86-4a7c-830e-5aa2a5ce0e15">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">12393</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:ProteinReference rdf:about="5fda32c4-8092-46cf-ad4b-1ccde2144722">
 <bp:entityFeature rdf:resource="fa3d813b-76b7-4865-abc3-28462945ab37" />
 <bp:xref rdf:resource="2357a00c-085a-4ceb-808c-9f597c96cbef" />
 <bp:organism rdf:resource="dc2dc0ae-8db8-4c40-b246-16b838e8df54" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">AKT1</bp:displayName>
</bp:ProteinReference>

<bp:ModificationFeature rdf:about="fa3d813b-76b7-4865-abc3-28462945ab37">
 <bp:modificationType rdf:resource="41af7d75-052c-487c-98ef-021f93d4a9d8" />
</bp:ModificationFeature>

<bp:Protein rdf:about="ae499673-d3f6-42b6-b9a9-e49efc439ed7">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">pmTOR</bp:displayName>
 <bp:entityReference rdf:resource="ae10c442-a493-4163-b447-569f97eb44d1" />
 <bp:notFeature rdf:resource="bbe1f82c-ee2c-4a71-8e78-601ff73b10a8" />
 <bp:notFeature rdf:resource="5d9cb1a4-c30e-4073-b0a4-617a654be3a2" />
</bp:Protein>

<bp:Control rdf:about="9291ffee-58bd-4c59-b0ec-91cb9bd7e799">
 <bp:controlled rdf:resource="3a9a6c1f-7bfa-46ba-9dd7-f35fdd15c196" />
 <bp:controller rdf:resource="42053bcf-4e93-420a-91b0-1373d54a8098" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">INHIBITION</bp:controlType>
</bp:Control>

<bp:Protein rdf:about="88d34051-d0b8-4776-83e6-f3657f46e08c">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">AKT1</bp:displayName>
 <bp:entityReference rdf:resource="5fda32c4-8092-46cf-ad4b-1ccde2144722" />
 <bp:notFeature rdf:resource="fa3d813b-76b7-4865-abc3-28462945ab37" />
</bp:Protein>

<bp:Protein rdf:about="f14d4528-13ad-4942-a82e-30704e2327ce">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">pmTOR</bp:displayName>
 <bp:feature rdf:resource="bbe1f82c-ee2c-4a71-8e78-601ff73b10a8" />
 <bp:feature rdf:resource="5d9cb1a4-c30e-4073-b0a4-617a654be3a2" />
 <bp:entityReference rdf:resource="ae10c442-a493-4163-b447-569f97eb44d1" />
</bp:Protein>

<bp:PublicationXref rdf:about="9870e8ad-ce7d-415d-8d29-d4fbb108eb95">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">35271849</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">pmid</bp:db>
</bp:PublicationXref>

<bp:Protein rdf:about="6aed25f2-c8db-4883-9a64-2b8f05146c76">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">AKT1</bp:displayName>
 <bp:entityReference rdf:resource="5fda32c4-8092-46cf-ad4b-1ccde2144722" />
</bp:Protein>

<bp:ProteinReference rdf:about="ae10c442-a493-4163-b447-569f97eb44d1">
 <bp:entityFeature rdf:resource="bbe1f82c-ee2c-4a71-8e78-601ff73b10a8" />
 <bp:entityFeature rdf:resource="5d9cb1a4-c30e-4073-b0a4-617a654be3a2" />
 <bp:xref rdf:resource="5cb461a2-c400-46c3-aab0-30a089845d28" />
 <bp:organism rdf:resource="dc2dc0ae-8db8-4c40-b246-16b838e8df54" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">pmTOR</bp:displayName>
</bp:ProteinReference>

<bp:RelationshipXref rdf:about="2357a00c-085a-4ceb-808c-9f597c96cbef">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">11651</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:Protein rdf:about="9228158f-b69b-4cec-a390-42b273664d29">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PKC eta</bp:displayName>
 <bp:entityReference rdf:resource="2ab6b20e-d3a1-44b7-a969-139d6c930e9f" />
</bp:Protein>

<bp:TemplateReactionRegulation rdf:about="c73e6729-a81a-48eb-b82f-b051820675bf">
 <bp:controlled rdf:resource="f452d86c-8937-40e3-9831-5a2d5b34e1ef" />
 <bp:controller rdf:resource="5949bd63-54d4-4c63-94dd-068602b3ddad" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">INHIBITION</bp:controlType>
</bp:TemplateReactionRegulation>

<bp:ModificationFeature rdf:about="5d9cb1a4-c30e-4073-b0a4-617a654be3a2">
 <bp:modificationType rdf:resource="efe95f0c-3332-4a8a-8b2b-ac977daeee07" />
</bp:ModificationFeature>

<bp:SmallMoleculeReference rdf:about="926fdb9f-1a6d-483e-93ff-20292f549c56">
 <bp:xref rdf:resource="86b3460a-851f-41da-9990-0f5b5a248255" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">miRNA (miR-exon4)</bp:displayName>
</bp:SmallMoleculeReference>

<bp:TemplateReaction rdf:about="f452d86c-8937-40e3-9831-5a2d5b34e1ef">
 <bp:product rdf:resource="ffcac9ba-bdc0-4355-86f8-712e705c8779" />
 <bp:participant rdf:resource="ffcac9ba-bdc0-4355-86f8-712e705c8779" />
</bp:TemplateReaction>

<bp:UnificationXref rdf:about="22a6e669-1a7c-4531-b528-d5810ff5acfd">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">10090</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">taxonomy</bp:db>
</bp:UnificationXref>

<bp:Protein rdf:about="42053bcf-4e93-420a-91b0-1373d54a8098">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">pmTOR</bp:displayName>
 <bp:entityReference rdf:resource="ae10c442-a493-4163-b447-569f97eb44d1" />
</bp:Protein>

<bp:RelationshipXref rdf:about="330aa3dc-b4e9-45a0-ba86-63371525c6b5">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">18755</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NCBI Gene</bp:db>
</bp:RelationshipXref>

<bp:SequenceModificationVocabulary rdf:about="41af7d75-052c-487c-98ef-021f93d4a9d8">
 <bp:term rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">active</bp:term>
</bp:SequenceModificationVocabulary>

<bp:Control rdf:about="3a9a6c1f-7bfa-46ba-9dd7-f35fdd15c196">
 <bp:controller rdf:resource="ffcac9ba-bdc0-4355-86f8-712e705c8779" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">INHIBITION</bp:controlType>
</bp:Control>

<bp:Rna rdf:about="ffcac9ba-bdc0-4355-86f8-712e705c8779">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Runx2</bp:displayName>
 <bp:entityReference rdf:resource="af256a24-da76-4319-9b7c-7c1ef03448f7" />
</bp:Rna>

<bp:Protein rdf:about="a7a057e3-d0dc-444a-b609-6f2c7b60bb6a">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">AKT1</bp:displayName>
 <bp:feature rdf:resource="fa3d813b-76b7-4865-abc3-28462945ab37" />
 <bp:entityReference rdf:resource="5fda32c4-8092-46cf-ad4b-1ccde2144722" />
</bp:Protein>

<bp:Rna rdf:about="5949bd63-54d4-4c63-94dd-068602b3ddad">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NFIA</bp:displayName>
 <bp:entityReference rdf:resource="f94a94a0-4f85-4cee-9206-09161bfbee1e" />
</bp:Rna>

<bp:Interaction rdf:about="9161f301-b7df-4fb0-abea-925959d50b35">
 <bp:participant rdf:resource="b5c6af1e-3e0a-46f5-ba74-ff6532d3bf66" />
 <bp:participant rdf:resource="ffcac9ba-bdc0-4355-86f8-712e705c8779" />
</bp:Interaction>

<bp:Conversion rdf:about="0ecd6353-910f-43f1-8ee5-14ad8baa9ef5">
 <bp:right rdf:resource="f14d4528-13ad-4942-a82e-30704e2327ce" />
 <bp:left rdf:resource="ae499673-d3f6-42b6-b9a9-e49efc439ed7" />
 <bp:conversionDirection rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">LEFT_TO_RIGHT</bp:conversionDirection>
</bp:Conversion>
</rdf:RDF>